comparative genomic and phylogenetic approaches to characterize the role of genetic recombination in mycobacterial evolution比较基因组和系统的方法来描述基因重组在分枝杆菌进化的作用.pdfVIP

Comparative Genomic and Phylogenetic Approaches to Characterize the Role of Genetic Recombination in Mycobacterial Evolution 1,2 3 1,2 2 Silvia E. Smith , Patrice Showers-Corneli , Caitlin N. Dardenne , Henry H. Harpending , 4 5 Darren P. Martin , Robert G. Beiko * 1 School of Medicine, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah, United States of America, 2 Department of Anthropology, University of Utah, Salt Lake City, Utah, United States of America, 3 Department of Biology, Univerity of Utah, Salt Lake City, Utah, United States of America, 4 Computational Biology Group, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa, 5 Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada Abstract The genus Mycobacterium encompasses over one hundred named species of environmental and pathogenic organisms, including the causative agents of devastating human diseases such as tuberculosis and leprosy. The success of these human pathogens is due in part to their ability to rapidly adapt to their changing environment and host. Recombination is the fastest way for bacterial genomes to acquire genetic material, but conflicting results about the extent of recombination in the genus Mycobacterium have been reported. We examined a data set comprising 18 distinct strains from 13 named species for evidence of recombination. Genomic regions common to all strains (accounting for 10% to 22% of the full genomes of all examined species) were aligned and concatenated in the chromosomal order of one mycobacterial reference species. The conc