circadian control of mouse heart rate and blood pressure by the suprachiasmatic nuclei behavioral effects are more significant than direct outputs生理控制鼠标的心率和血压的视交叉上核行为影响是更重要的比直接输出.pdfVIP

Circadian Control of Mouse Heart Rate and Blood Pressure by the Suprachiasmatic Nuclei: Behavioral Effects Are More Significant than Direct Outputs 1 2 3 3 1 W. John Sheward , Erik Naylor , Seymour Knowles-Barley , J. Douglas Armstrong , Gillian A. Brooker , 1 4 1 2 1 Jonathan R. Seckl , Fred W. Turek , Megan C. Holmes , Phyllis C. Zee , Anthony J. Harmar * 1 Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom, 2 Department of Neurology, Northwestern University Medical School, Chicago, Illinois, United States of America, 3 Institute for Adaptive and Neural Computation, University of Edinburgh, Edinburgh, United Kingdom, 4 Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America Abstract Background: Diurnal variations in the incidence of events such as heart attack and stroke suggest a role for circadian rhythms in the etiology of cardiovascular disease. The aim of this study was to assess the influence of the suprachiasmatic nucleus (SCN) circadian clock on cardiovascular function. Methodology/Principal Findings: Heart rate (HR), blood pressure (BP) and locomotor activity (LA) were measured in circadian mutant (Vipr22/ 2) mice and wild type littermates, using implanted radio-telemetry devices. Sleep and wakefulness were studied in similar mice implanted with electroencephalograph (EEG) electrodes. There was less diurnal variation in the frequency and duration of bouts of rest/activity and sleep/wake in Vipr22/ 2 mice than in wild type (WT) and short ‘‘