原创力文档comparison of bone and renal effects in hiv-infected adults switching to abacavir or tenofovir based therapy in a randomized trial比较骨和肾功能的影响在感染艾滋病毒的成年人转向abacavir或替诺福韦治疗的随机试验.pdfVIP
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comparison of bone and renal effects in hiv-infected adults switching to abacavir or tenofovir based therapy in a randomized trial比较骨和肾功能的影响在感染艾滋病毒的成年人转向abacavir或替诺福韦治疗的随机试验
Comparison of Bone and Renal Effects In HIV-infected
Adults Switching to Abacavir or Tenofovir Based Therapy
in a Randomized Trial
1 2 1 1 3
Thomas A. Rasmussen *, Danny Jensen , Martin Tolstrup , Ulla S. Nielsen , Erland J. Erlandsen ,
2 1 4 1
Henrik Birn , Lars Østergaard , Bente L. Langdahl , Alex L. Laursen
1 Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark, 2 Department of Nephrology, Aarhus University Hospital and Institute of Biomedicine,
Aarhus University, Aarhus, Denmark, 3 Department of Clinical Biochemistry, Viborg Regional Hospital, Viborg, Denmark, 4 Department of Endocrinology and Internal
Medicine, Aarhus University Hospital, Aarhus, Denmark
Abstract
Introduction: Our objective was to compare the bone and renal effects among HIV-infected patients randomized to
abacavir or tenofovir-based combination anti-retroviral therapy.
Methods: In an open-label randomized trial, HIV-infected patients were randomized to switch from zidovudine/lamivudine
(AZT/3TC) to abacavir/lamivudine (ABC/3TC) or tenofovir/emtricitabine (TDF/FTC). We measured bone mass density (BMD)
and bone turnover biomarkers (osteocalcin, osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), alkaline
phosphatase, type I collagen cross-linked C-telopeptide (CTx), and osteoprotegerin). We assessed renal function by
estimated creatinine clearance, plasma cystatin C, and urinary levels of creatinine, albumin, cystatin C, and neutrophil
gelatinase-associated lipocalin (NGAL). The changes from baseline in BMD and renal and bone biomarkers were c
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