原创力文档comparison of the gene expression profiles from normal and fgfrl1 deficient mouse kidneys reveals downstream targets of fgfrl1 signaling基因表达谱的比较正常和fgfrl1缺陷小鼠肾脏显示下游fgfrl1信号的目标.pdfVIP
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comparison of the gene expression profiles from normal and fgfrl1 deficient mouse kidneys reveals downstream targets of fgfrl1 signaling基因表达谱的比较正常和fgfrl1缺陷小鼠肾脏显示下游fgfrl1信号的目标
Comparison of the Gene Expression Profiles from Normal
and Fgfrl1 Deficient Mouse Kidneys Reveals Downstream
Targets of Fgfrl1 Signaling
1¤ 1 1 1,2
Simon D. Gerber , Ruth Amann , Stefan Wyder , Beat Trueb *
1 Department of Clinical Research, University of Bern, Bern, Switzerland, 2 Department of Rheumatology, University Hospital, Bern, Switzerland
Abstract
Fgfrl1 (fibroblast growth factor receptor-like 1) is a transmembrane receptor that is essential for the development of the
metanephric kidney. It is expressed in all nascent nephrogenic structures and in the ureteric bud. Fgfrl1 null mice fail to
develop the metanephric kidneys. Mutant kidney rudiments show a dramatic reduction of ureteric branching and a lack of
mesenchymal-to-epithelial transition. Here, we compared the expression profiles of wildtype and Fgfrl1 mutant kidneys to
identify genes that act downstream of Fgfrl1 signaling during the early steps of nephron formation. We detected 56
differentially expressed transcripts with 2-fold or greater reduction, among them many genes involved in Fgf, Wnt, Bmp,
Notch, and Six/Eya/Dach signaling. We validated the microarray data by qPCR and whole-mount in situ hybridization and
showed the expression pattern of candidate genes in normal kidneys. Some of these genes might play an important role
during early nephron formation. Our study should help to define the minimal set of genes that is required to form a
functional nephron.
Citation: Gerber SD, Amann R, Wyder S, Trueb B (2012) Comparison of the Gene Expression Profiles from Normal and Fgfrl1 Deficient Mouse Kidneys Reveals
Downstream Targets of Fgfrl1 Signaling. PLoS ONE 7(3): e33457. doi:10.1371/journal.pone.0033457
Editor: Arun Rishi, Wayne State University, Un
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