coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer协调候选人原癌基因的激活和癌症通过启动子脱甲基睾丸抗原在头颈癌和肺癌.pdfVIP

Coordinated Activation of Candidate Proto-Oncogenes and Cancer Testes Antigens via Promoter Demethylation in Head and Neck Cancer and Lung Cancer 1 1 2 3 1 1 Ian M. Smith , Chad A. Glazer , Suhail K. Mithani , Michael F. Ochs , Wenyue Sun , Sheetal Bhan , 5 5 5 1 1 Alexander Vostrov , Ziedulla Abdullaev , Victor Lobanenkov , Andrew Gray , Chunyan Liu , Steven S. 1 1 4 4 1 Chang , Kimberly L. Ostrow , William H. Westra , Shahnaz Begum , Mousumi Dhara , Joseph Califano1,6* 1 Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, 2 Department of Surgery, Division of Plastic and Reconstructive Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, 3 Division of Oncology Biostatistics, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, 4 Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, 5 Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, Maryland, United States of America, 6 Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland, United States of America Abstract Background: Epigenetic alterations have been implicated in the pathogenesis of solid tumors, however, proto-oncogenes activated by promoter demethylation have been sporadically reported. We used an integrative method to analyze