correlation between multi-drug resistance-associated membrane transport in clonal cancer cells and the cell cycle phase多种药物之间的相关性resistance-associated克隆癌细胞膜运输和细胞周期阶段.pdfVIP

Correlation between Multi-Drug Resistance-Associated Membrane Transport in Clonal Cancer Cells and the Cell Cycle Phase Vasilij Koshkin, Sergey N. Krylov* Centre for Research on Biomolecular Interactions, York University, Toronto, Ontario, Canada Abstract Multidrug resistance driven by ABC membrane transporters is one of the major reasons for treatment failure in human malignancy. Some limited evidence has previously been reported on the cell cycle dependence of ABC transporter expression. However, it has n