cortical gamma rhythms modulate nmdar-mediated spike timing dependent plasticity in a biophysical model皮质gamma节律调节nmdar-mediated高峰时间相关的可塑性在生物物理模型.pdfVIP

Cortical Gamma Rhythms Modulate NMDAR-Mediated Spike Timing Dependent Plasticity in a Biophysical Model Shane Lee1,2*, Kamal Sen1,2,3,4, Nancy Kopell1,2,5 1 Program in Neuroscience, Boston University, Boston, Massachusetts, United States of America, 2 Center for Biodynamics, Boston University, Boston, Massachusetts, United States of America, 3 Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America, 4 Hearing Research Center, Boston University, Boston, Massachusetts, United States of America, 5 Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, United States of America Abstract Spike timing dependent plasticity (STDP) has been observed experimentally in vitro and is a widely studied neural algorithm for synaptic modification. While the functional role of STDP has been investigated extensively, the effect of rhythms on the precise timing of STDP has not been characterized as well. We use a simplified biophysical model of a cortical network that generates pyramidal interneuronal gamma rhythms (PING). Plasticity via STDP is investigated at the excitatory pyramidal cell synapse from a gamma frequency (30–90 Hz) input independent of the network gamma rhythm. The input may represent a corticocortical or an information-specific thalamocortical connection. This synapse is mediated by N-methyl-D-aspartate receptor mediated (NMDAR) currents. For distinct network and input frequencies, the model shows robust frequency regimes of potentiation and depression, providing a mechanism by which responses to certain inputs can potentiate while responses to other inputs depress. For potentiating regimes, the model suggests an optimal amount and duration of plasticity that can occur, which depends on the time course for the decay of the postsynaptic NMDAR curre