crmp5 regulates generation and survival of newborn neurons in olfactory and hippocampal neurogenic areas of the adult mouse braincrmp5调节生成和新生神经元的生存嗅觉和海马神经源性地区的成年老鼠的大脑.pdfVIP

CRMP5 Regulates Generation and Survival of Newborn Neurons in Olfactory and Hippocampal Neurogenic Areas of the Adult Mouse Brain 1 2 ¨ 1 2 2 Alexandra Veyrac , Sophie Reibel , Joelle Sacquet , Mireille Mutin , Jean-Philippe Camdessanche , 3 ´ ˆ 2 1 Pappachan Kolattukudy , Jerome Honnorat , Franc¸ois Jourdan * ´ ´ 1Team Neuroplasticity and Neuropathology of Olfactory Perception, Lyon Neuroscience Research Center INSERM U 1028/CNRS UMR 5292, Universite de Lyon - Universite ´ Claude Bernard Lyon 1, Lyon, France, 2 Team Neuro-Oncology and Neuro-Inflammation, Lyon Neuroscience Research Center INSERM U 1028/CNRS UMR 5292, Universite ´ ´ de Lyon - Universite Claude Bernard Lyon 1, Faculte Laennec, Lyon, France, 3 Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, United States of America Abstract The Collapsin Response Mediator Proteins (CRMPs) are highly expressed in the developing brain, and in adult brain areas that retain neurogenesis, ie: the olfactory bulb (OB) and the dentate gyrus (DG). During brain development, CRMPs are essentially involved in signaling of axon guidance and neurite outgrowth, but their functions in the adult brain remain largely unknown. CRMP5 has been initially identified as