cycles and the qualitative evolution of chemical systems周期和化学的定性演化系统.pdfVIP

Cycles and the Qualitative Evolution of Chemical Systems 1 1 2 3 1,4 1 Peter Kreyssig , Gabi Escuela , Bryan Reynaert , Tomas Veloz , Bashar Ibrahim *, Peter Dittrich * 1 Bio Systems Analysis Group, Institute of Computer Science, Jena Centre for Bioinformatics and Friedrich Schiller University, Jena, Germany, 2 Faculty of Biological Sciences, University of Chile, Santiago, Chile, 3 Department of Psychology and Computer Science, University of British Columbia, Kelowna, Canada, 4 German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany Abstract Cycles are abundant in most kinds of networks, especially in biological ones. Here, we investigate their role in the evolution of a chemical reaction system from one self-sustaining composition of molecular species to another and their influence on the stability of these compositions. While it is accepted that, from a topological standpoint, they enhance network robustness, the consequence of cycles to the dynamics are not well understood. In a former study, we developed a necessary criterion for the existence of a fixed point, which is purely based on topological properties of the network. The structures of interest we identified were a generalization of closed autocatalytic sets, called chemical organizations. Here, we show that the existence of these chemical organizations and therefore steady states is linked to the existence of cycles. Importantly, we provide a criterion for a qualitative transition, namely a transition from one self-sustaining set of molecular species to another via the introduction of a cycle. Because results purely bas