copy number variation across european populations在欧洲人拷贝数变异.pdfVIP

Copy Number Variation across European Populations 1 2 2 3 2 4 Wanting Chen , Caroline Hayward , Alan F. Wright , Andrew A. Hicks , Veronique Vitart , Sara Knott , 5 3,6,7 5 5,8 1 Sarah H. Wild , Peter P. Pramstaller , James F. Wilson , Igor Rudan , David J. Porteous * 1 Medical Genetics Section, Centre for Molecular Medicine, Institute of Genetics Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, United Kingdom, 2 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom, ¨ ¨ 3 Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, Italy - Affiliated Institute of the University of Lubeck, Lubeck, Germany, 4 Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King’s Buildings, Edinburgh, United Kingdom, 5 Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom, 6 Department of Neurology, General Central Hospital, Bolzano, Italy, 7 Department of ¨ ¨ Neurology, University of Lubeck, Lubeck, Germany, 8 Croatian Centre for Global Health, University of Split Medical School, Split, Croatia Abstract Genome analysis provides a powerful approach to test for evidence of genetic variation within and between geographical regions and local