copy number variation and transposable elements feature in recent, ongoing adaptation at the cyp6g1 locus在最近的拷贝数变异和转座的元素特性,不断适应cyp6g1轨迹.pdfVIP

Copy Number Variation and Transposable Elements Feature in Recent, Ongoing Adaptation at the Cyp6g1 Locus 1,2,3 1,3 1 1 1,3 Joshua M. Schmidt , Robert T. Good , Belinda Appleton , Jayne Sherrard , Greta C. Raymant , 1,2 1 1,2,3 4,5 1,2,3 Michael R. Bogwitz , Jon Martin , Phillip J. Daborn , Mike E. Goddard , Philip Batterham , Charles Robin1,3* 1 Department of Genetics, The University of Melbourne, Parkville, Victoria, Australia, 2 Centre for Environmental Stress and Adaptation Research, The University of Melbourne, Parkville, Victoria, Australia, 3 The Bio21 Institute, The University of Melbourne, Parkville, Victoria, Australia, 4 Department of Agriculture and Food Systems, The University of Melbourne, Parkville, Victoria, Australia, 5 Department of Primary Industries, Bioscience Research Division, Bundoora, Victoria, Australia Abstract The increased transcription of the Cyp6g1 gene of Drosophila melanogaster, and consequent resistance to insecticides such as DDT, is a widely cited example of adaptation mediated by cis-regulatory change. A fragment of an Accord transposable element inserted upstream of the Cyp6g1 gene is causally associated with resistance and has spread to high frequencies in populations around the world since the 1940s. Here we report the existence of a natural allelic series at this locus of D. melanogaster, involving copy number variation of Cyp6g1, and two additional transposable element insertions (a P and an HMS-Beagle). We provide evidence that this genetic variatio