cyproheptadine enhances the ik of mouse cortical neurons through sigma-1 receptor-mediated intracellular signal pathway赛庚啶增强小鼠皮层神经元的动力学通过sigma 1受体介导细胞内信号通路.pdfVIP

Cyproheptadine Enhances the IK of Mouse Cortical Neurons through Sigma-1 Receptor-Mediated Intracellular Signal Pathway Yan-Lin He, Chun-Lei Zhang, Xiao-Fei Gao, Jin-Jing Yao, Chang-Long Hu, Yan-Ai Mei* Institutes of Brain Science, School of Life Sciences and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China Abstract Cyproheptadine (CPH) is a histamine- and serotonin-receptor antagonist, and its effects are observed recently in the modulation of multiple intracellular signals. In this study, we used cortical neurons and HEK-2