原创力文档deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks破译疾病和生物环境化学品使用toxicogenomics网络的目标.pdfVIP
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deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks破译疾病和生物环境化学品使用toxicogenomics网络的目标
Deciphering Diseases and Biological Targets for
Environmental Chemicals using Toxicogenomics
Networks
Karine Audouze, Agnieszka Sierakowska Juncker, Francisco J. S. S. A. Roque, Konrad Krysiak-Baltyn, Nils
Weinhold, Olivier Taboureau, Thomas Skøt Jensen, Søren Brunak*
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
Abstract
Exposure to environmental chemicals and drugs may have a negative effect on human health. A better understanding of
the molecular mechanism of such compounds is needed to determine the risk. We present a high confidence human
protein-protein association network built upon the integration of chemical toxicology and systems biology. This
computational systems chemical biology model reveals uncharacterized connections between compounds and diseases,
thus predicting which compounds may be risk factors for human health. Additionally, the network can be used to identify
unexpected potential associations between chemicals and proteins. Examples are shown for chemicals associated with
breast cancer, lung cancer and necrosis, and potential protein targets for di-ethylhexyl-phthalate, 2,3,7,8-tetrachlorodiben-
zo-p-dioxin, pirinixic acid and permethrine. The chemical-protein associations are supported through recent published
studies, which illustrate the power of our approach that integrates toxicogenomics data with other data types.
Citation: Audouze K, Juncker AS, Roque FJSSA, Krysiak-Baltyn K, Weinhold N, et al. (2010) Deciphering Diseases and Biological Targets for Environmental
Chemicals using Toxicogenomics Networks. PLoS Comput Biol 6(5): e1000788. doi:10.1371/journal.pcbi.1000788
Editor: Olaf G. Wiest, University of Notre Dame, United States of America
Received September 11, 2009; Accepted Apri
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