原创力文档degenerate wave and capacitive coupling increase human msc invasion and proliferation while reducing cytotoxicity in an in vitro wound healing model退化波和电容耦合增加人类msc入侵和扩散,同时减少细胞毒性的体外伤口愈合模型.pdfVIP
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degenerate wave and capacitive coupling increase human msc invasion and proliferation while reducing cytotoxicity in an in vitro wound healing model退化波和电容耦合增加人类msc入侵和扩散,同时减少细胞毒性的体外伤口愈合模型
Degenerate Wave and Capacitive Coupling Increase
Human MSC Invasion and Proliferation While Reducing
Cytotoxicity in an In Vitro Wound Healing Model
1 1 1 2 1,3,4
Michelle Griffin , Syed Amir Iqbal , Anil Sebastian , James Colthurst , Ardeshir Bayat *
1 Plastic Reconstructive Surgery Research, School of Translational Medicine, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United
Kingdom, 2 Fenzian Limited, Hungerford, Berkshire, United Kingdom, 3 Department of Plastic and Reconstructive Surgery, South Manchester University Hospital
Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom, 4 Manchester Academic Health Science Centre, South Manchester University Hospital Foundation
Trust, Wythenshawe Hospital, The University of Manchester, Manchester, United Kingdom
Abstract
Non-unions pose complications in fracture management that can be treated using electrical stimulation (ES). Bone marrow
mesenchymal stem cells (BMMSCs) are essential in fracture healing; however, the effect of different clinical ES waveforms on
BMMSCs cellular activities remains unknown. We compared the effects of direct current (DC), capacitive coupling (CC),
pulsed electromagnetic field (PEMF) and degenerate wave (DW) on cellular activities including cytotoxicity, proliferation,
cell-kinetics and apoptosis by stimulating human-BMMSCs 3 hours a day, up to 5 days. In addition, migration and invasion
were assessed using fluorescence microscopy and by quantifying gene and protein expression. We found that DW had the
greatest proliferative and least apoptotic and cytotoxic effects compared to other waveforms. DC, DW and CC stimulations
resulted in a higher number of cells in S
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