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PLoS MEDICINE Deployment of Early Diagnosis and Mefloquine- Artesunate Treatment of Falciparum Malaria in Thailand: The Tak Malaria Initiative 1,2,3 4 4 5 1 Verena Ilona Carrara , Supakit Sirilak , Janjira Thonglairuam , Chaiporn Rojanawatsirivet , Stephane Proux , Valery Gilbos1 1,2 1,2,6 1,2,6 2 2 , Al Brockman , Elizabeth A. Ashley , Rose McGready , Srivicha Krudsood , Somjai Leemingsawat , Sornchai Looareesuwan3 3 2,6 1,2,6* , Pratap Singhasivanon , Nicholas White , Franc¸ois Nosten 1 Shoklo Malaria Research Unit, Tak, Thailand, 2 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 3 Departments of Medical Entomology, Tropical Hygiene and Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 4 Public Health Office, Tak, Thailand, 5 Ministry of Public Health, Nonthaburi, Thailand, 6 Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom Funding: The Tak Malaria Initiative A B S T R A C T was supported by a grant from The Bill and Melinda Gates Foundation. Background The IEC campaign was supported by the International Rescue Committee (IRC) and USAID. The funders had no Early diagnosis and treatment with artesunate-mefloquine combination therapy (MAS) have role in study design, data collection reduced the transmission of falciparum malaria dramatically and halted the progression of and an