design principles of a genetic alarm clock遗传闹钟的设计原则.pdfVIP

Design Principles of a Genetic Alarm Clock Jaroslav Albert*, Marianne Rooman ´ BioModeling, BioInformatics and BioProcesses Department, Universite Libre de Bruxelles, Bruxelles, Belgium Abstract Turning genes on and off is a mechanism by which cells and tissues make phenotypic decisions. Gene network motifs capable of supporting two or more steady states and thereby providing cells with a plurality of possible phenotypes are referred to as genetic switches. Modeled on the bases of