原创力文档differential effects of short term feeding of a soy protein isolate diet and estrogen treatment on bone in the pre-pubertal rat微分的影响短期内喂养的大豆分离蛋白饮食和雌激素治疗的骨pre-pubertal老鼠.pdfVIP
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differential effects of short term feeding of a soy protein isolate diet and estrogen treatment on bone in the pre-pubertal rat微分的影响短期内喂养的大豆分离蛋白饮食和雌激素治疗的骨pre-pubertal老鼠
Differential Effects of Short Term Feeding of a Soy
Protein Isolate Diet and Estrogen Treatment on Bone in
the Pre-Pubertal Rat
1,2 1,3 1,3 1 1,3
Jian Zhang , Oxana P. Lazarenko , Xianli Wu , Yudong Tong , Michael L. Blackburn ,
Horatio Gomez-Acevedo1, Kartik Shankar1,2, Thomas M. Badger1,2,3, Martin J. J. Ronis1,2,4, Jin-
Ran Chen1,2*
1 Arkansas Children’s Nutrition Center, Little Rock, Arkansas, United States of America, 2 Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock,
Arkansas, United States of America, 3 Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of
America, 4 Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
Abstract
Background: Previous reports suggest that beneficial effects of soy on bone quality are due to the estrogenic actions of
isoflavone phytochemicals associated with the protein. However, mechanistic studies comparing the effects of soy diet and
estrogens on bone, particularly in rapidly growing animals are lacking.
Methodology and Principal Findings: We studied the effects of short term feeding of soy protein isolate (SPI) on bone in
comparison to the effects of 17b-estradiol (E2) in pre-pubertal rats. Female rats were weaned to one of 4 treatments: 1) a
control casein-based diet (CAS); 2) CAS with subcutaneous E2 (10 mg/kg/d) (CAS+E2); 3) a SPI-containing diet (SPI); or 4) SPI
with subcutaneous E2 (SPI) or SPI with 10 mg/kg/d E2 (SPI+E2) for 14 days beginning on postnatal day 20. SPI increased
while E2 decreased bone turnover compared to CAS. In contrast, both treatments
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