differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease微分调节循环水平的分子陪伴在病人接受治疗牙周疾病.pdfVIP

Differential Regulation of Circulating Levels of Molecular Chaperones in Patients Undergoing Treatment for Periodontal Disease 1,2. 3. 3 4 2 3 3 Alireza Shamaei-Tousi *, Francesco D’Aiuto , Luigi Nibali , Andrew Steptoe , Anthony R. M. Coates , Mohamed Parkar , Nikos Donos , Brian Henderson1 1 Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom, 2 St George’s Hospital Medical School, London, United Kingdom, 3 Periodontology Unit, UCL Eastman Dental Institute and Hospital, University College London, London, United Kingdom, 4 Department of Epidemiology and Public Health, University College London, London, United Kingdom Background. Evidence is emerging that molecular chaperones, in addition to their intracellular protein folding actions, can act as intercellular signaling proteins with an ability to modulate leukocyte function. Recent evidence has also shown that these proteins can exist in the circulation and may be involved in disease pathogenesis. We have used periodontitis and its treatment as a model of inflammation in the human to determine its effects on levels of circulating HSP10, HSP60 and BiP. Methodology/Principal Findings. A group of periodontal patients and matched controls were examined at the beginning of the study and then at 1 day and 6 months following periodontal or control therapy. Plasma levels of HSP10, HSP60 and BiP were measured by immunoassay and related to other plasma measures of inflammation. Periodontal patients had significantly less circulating levels of HSP10 or BiP compared with the controls. In contrast, more periodontal patients had intermediate levels of HSP60. Treatment of the periodontitis caused an increase in plasma levels of HSP10 although it had no effect on BiP. Treatm