differentially evolved genes of salmonella pathogenicity islands insights into the mechanism of host specificity in salmonella沙门氏菌的致病性的差异进化基因岛见解沙门氏菌的宿主特异性的机制.pdfVIP

Differentially Evolved Genes of Salmonella Pathogenicity Islands: Insights into the Mechanism of Host Specificity in Salmonella 1 1 1 1 Sandeepa M. Eswarappa , Jessin Janice , Arvindhan G. Nagarajan , Sudhagar V. Balasundaram , 1 2 1 Guruswamy Karnam , Narendra M. Dixit , Dipshikha Chakravortty * 1 Department of Microbiology and Cell Biology, Centre for Infectious Disease Research and Biosafety Laboratories, Indian Institute of Science, Bangalore, India, 2 Department of Chemical Engineering, Centre for Infectious Disease Research and Biosafety Laboratories, Indian Institute of Science, Bangalore, India Abstract Background: The species Salmonella enterica (S. enterica) includes many serovars that cause disease in avian and mammalian hosts. These serovars differ greatly in their host range and their degree of host adaptation. The host specificity of S. enterica serovars appears to be a complex phenomenon governed by multiple factors acting at different stages of the infection process, which makes identification of the cause/s of host specificity solely by experimental methods difficult. Methodology/Principal Findings: In this study, we have employed a molecular evolution and phylogenetics based approach to identify genes that might play important roles in conferring host specificity to different serovars of S. enterica. These genes are ‘differentially evolved’ in different S. enterica serovars. This list of ‘differentially evolved’ genes includes genes that encode translocon proteins (SipD, SseC and SseD) of both Salmonella pathogenicity islands 1 and 2 e