direct identification of insulator components by insertional chromatin immunoprecipitation直接识别的绝缘子组件插入染色质免疫沉淀反应.pdfVIP

Direct Identification of Insulator Components by Insertional Chromatin Immunoprecipitation Toshitsugu Fujita, Hodaka Fujii* Combined Program on Microbiology and Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan Abstract Comprehensive understanding of mechanisms of epigenetic regulation requires identification of molecules bound to genomic regions of interest in vivo. However, non-biased methods to identify molecules bound to specific genomic loci in vivo are limited. Here, we applied insertional chromatin immunoprecipi