direct presentation is sufficient for an efficient anti-viral cd8+ t cell response直接的表现足以让一个高效抗病毒cd8 + t细胞的反应.pdfVIP

Direct Presentation Is Sufficient for an Efficient Anti-Viral CD8+ T Cell Response Ren-Huan Xu, Sanda Remakus, Xueying Ma, Felicia Roscoe, Luis J. Sigal* Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America Abstract The extent to which direct- and cross-presentation (DP and CP) contribute to the priming of CD8+ T cell (TCD8+) responses to viruses is unclear mainly because of the difficulty in separating the two processes. Hence, while CP in the absence of DP has been clearly demonstrated, induction of an anti-viral TCD8+ re