diagnosis of soil-transmitted helminths in the era of preventive chemotherapy effect of multiple stool sampling and use of different diagnostic techniques诊断土壤传播寄生虫的时代预防化疗效果的多个凳子上采样和使用不同的诊断技术.pdfVIP

Diagnosis of Soil-Transmitted Helminths in the Era of Preventive Chemotherapy: Effect of Multiple Stool Sampling and Use of Different Diagnostic Techniques 1 2{ 2 1,3 4 Stefanie Knopp , Ali F. Mgeni , I. Simba Khamis , Peter Steinmann , J. Russell Stothard , David 4 5 ¨ 1 Rollinson , Hanspeter Marti , Jurg Utzinger * 1 Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland, 2 Helminth Control Laboratory Unguja, Ministry of Health and Social Welfare, Zanzibar, Tanzania, 3 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People’s Republic of China, 4 Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, United Kingdom, 5 Department of Medical and Diagnostic Services, Swiss Tropical Institute, Basel, Switzerland Abstract Background: Soil-transmitted helminth infections are common throughout the tropics and subtropics and they disproportionately affect the poorest of the poor. In view of a growing global commitment to control soil-transmitted helminthiasis, there is a need to elucidate the effect of repeated stool sampling and the use of different diagnostic methods in areas targeted for preventive chemotherapy that are characterized by low-infection intensities. In this study, we focused on schoolchildren on Unguja Island, Zanzibar, an area where anthelminthic drugs have been repeatedly administered over the past decade. Methodology/Principal Findings: Three serial stool samples from each of 342 schoolchildren were examined using the Kato-