discarding functional residues from the substitution table improves predictions of active sites within three-dimensional structures丢弃功能残留物从替换表改善活动网站在三维结构的预测.pdfVIP

Discarding Functional Residues from the Substitution Table Improves Predictions of Active Sites within Three- Dimensional Structures Sungsam Gong, Tom L. Blundell* Biocomputing Group, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom Abstract Substitutions of individual amino acids in proteins may be under very different evolutionary restraints depending on their structural and functional roles. The Environment Specific Substitution Table (ESST) describes the pattern of substitutions in terms of amino acid location within elements of se