distribution of hla-a, -b and -drb1 genes and haplotypes in the tujia population living in the wufeng region of hubei province, china分布的抗原,- b和-drb1基因和单体型土家族人口生活在湖北省聚地区的中国.pdfVIP

Distribution of HLA-A, -B and -DRB1 Genes and Haplotypes in the Tujia Population Living in the Wufeng Region of Hubei Province, China 1 2 3 1 4 5 1 Li Zhang , Dangxiao Cheng , Ning Tao , Min Zhao , Fan Zhang , Yulin Yuan , Xiaoping Qiu * 1 Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China, 2 University of Toronto, Toronto, Ontario, Canada, 3 Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 4 Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China, 5 Department of Dissection, Medical School of Wuhan University, Wuhan, Hubei, China Abstract Background: The distribution of HLA alleles and haplotypes varies widely between different ethnic populations and geographic areas. Before any genetic marker can be used in a disease-associated study it is therefore essential to investigate allelic frequencies and establish a genetic database. Methodology/Principal Findings: This is the first report of HLA typing in the Tujia group using the Luminex HLA-SSO method HLA–A, –B and -DRB1 allelic distributions were determined in 124 unrelated healthy Tujia individuals, and haplotypic frequencies and linkage disequilibrium parameters were estimated using the maximum-likelihood method. In total 10 alleles were detected at the HLA–A locus, 21 alleles at the HLA–B locus and 14 alleles at the HLA-DRB1 locus. The most frequently observed alleles in the HLA-I group were HLA–A*02 (35.48%), A*11 (28.23%), A*24 (15.73%); HLA–B*40 (25.00%), B*46 (16.13%), and B*15 (15.73%). Among HLA-DRB1 alleles, high frequencies of HLA-DRB1*09 (25.81%) were observed, followed by HLA-DRB1*15 (12.9%), and DRB1*12 (10.89%). The two-locus haplotypes at the highest f