dynamic chromatin organization during foregut development mediated by the organ selector gene pha-4foxa动态染色质组织在前肠发育的器官pha-4foxa选择基因.pdfVIP

Dynamic Chromatin Organization during Foregut Development Mediated by the Organ Selector Gene PHA-4/FoxA Tala H. I. Fakhouri, Jeff Stevenson¤a, Andrew D. Chisholm¤b, Susan E. Mango* Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America Abstract Central regulators of cell fate, or selector genes, establish the identity of cells by direct regulation of large cohorts of genes. In Caenorhabditis elegans, foregut (or pharynx) identity relies on the FoxA transcription factor PHA-4, which activates