ebola and marburg hemorrhagic fevers neglected tropical diseases埃博拉和马尔堡出血热被忽视的热带疾病.pdfVIP

Review Ebola and Marburg Hemorrhagic Fevers: Neglected Tropical Diseases? Adam MacNeil*, Pierre E. Rollin Viral Special Pathogens Branch, the Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America with human disease [15,16]). Clusters and outbreaks are primarily Abstract: Ebola hemorrhagic fever (EHF) and Marburg the result of person-to-person transmission of these viruses, which hemorrhagic fever (MHF) are rare viral diseases, endemic occurs through direct contact with the body, bodily fluids to central Africa. The overall burden of EHF and MHF is (commonly to health care workers), or contaminated clothes or small in comparison to the more common protozoan, linens of an infected person [17–21]. The level of viremia, and helminth, and bacterial diseases typically referred to as thus presumptively the risk of transmission, corresponds with neglected tropical diseases (NTDs). However, EHF and disease severity, with highest concentrations of the virus during MHF outbreaks typically occur in resource-limited set- tings, and many aspects of these outbreaks are a direct later stages of disease [22,23]. consequence of impoverished conditions. We will discuss Three distinct contact modalities account for virus transmission aspects of EHF and MHF disease, in comparison to the during ou