dominance of objects over context in a mediotemporal lobe model of schizophrenia主导地位的对象上下文mediotemporal叶模型的精神分裂症.pdfVIP

Dominance of Objects over Context in a Mediotemporal Lobe Model of Schizophrenia 1 2 Lucia M. Talamini *, Martijn Meeter 1 Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands, 2 Department of Cognitive Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands Abstract Background: A large body of evidence suggests impaired context processing in schizophrenia. Here we propose that this impairment arises from defective integration of mediotemporal ‘what’ and ‘where’ routes, carrying object and spatial information to the hippocampus. Methodology and Findings: We have previously shown, in a mediotemporal lobe (MTL) model, that the abnormal connectivity between MTL regions observed in schizophrenia can explain the episodic memory deficits associated with the disorder. Here we show that the same neuropathology leads to several context processing deficits observed in patients with schizophrenia: 1) failure to choose subordinate stimuli over dominant ones when the former fit the context, 2) decreased contextual constraints in memory retrieval, as reflected in increased false alarm rates and 3) impaired retrieval of contextual information in source monitoring. Model analyses show that these deficits occur because the ‘schizophrenic MTL’ forms fragmented episodic representations, in which objects are overrepresented at the expense of spatial contextual information. Conclusions and Significance: These findings highlight the importance of MTL neuropathology in schizophrenia, demonstrating that it may underlie a broad spectrum of deficits, including context processing and memory impairments. It is argued that