disproportionate alterations in the anterior and posterior insular cortices in obsessive–compulsive disorder不成比例的改变在前部和后部岛皮质强迫症.pdfVIP

Disproportionate Alterations in the Anterior and Posterior Insular Cortices in Obsessive–Compulsive Disorder 1 1 2 2 2 2 Aram Song , Wi Hoon Jung , Joon Hwan Jang , Euitae Kim , Geumsook Shim , Hye Yoon Park , Chi- Hoon Choi3, Jun Soo Kwon1,2,4* 1 Interdisciplinary Program in Neuroscience, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea, 2 Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea, 3 Department of Radiology, National Medical Center, Seoul, Republic of Korea, 4 Brain and Cognitive Sciences—World Class University Program, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea Abstract Background: Recent studies have reported that the insular cortex is involved in the pathophysiology of obsessive– compulsive disorder (OCD). However, specific morphometric abnormalities of the insular subregions remain unclear. In this study, we examined insular cortical volume to determine whether the volume of the anterior and posterior insular cortices of unmedicated OCD patients differed according to different symptom dimensions. Methods/Principal Findings: Using magnetic resonance imaging, we measured the gray matter volumes of the insular ¨ cortex and its subregions (anterior and posterior divisions) in 41 patients with OCD (31 drug-naıve and 10 non-medicated) and 53 healthy controls. Volumetric measures of the insular cortex were compared according to different OC symptoms. Enlarged anterior and reduced po