differential effects of hoxb4 on nonhuman primate short- and long-term repopulating cells微分hoxb4对非人灵长类动物的短期和长期的影响细胞重新繁衍.pdfVIP

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differential effects of hoxb4 on nonhuman primate short- and long-term repopulating cells微分hoxb4对非人灵长类动物的短期和长期的影响细胞重新繁衍.pdf

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differential effects of hoxb4 on nonhuman primate short- and long-term repopulating cells微分hoxb4对非人灵长类动物的短期和长期的影响细胞重新繁衍

PLoS MEDICINE Differential Effects of HOXB4 on Nonhuman Primate Short- and Long-Term Repopulating Cells 1 1 1 1,2 3,4 1,5* Xiao-Bing Zhang , Brian C. Beard , Katherine Beebe , Barry Storer , R. Keith Humphries , Hans-Peter Kiem 1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 2 Department of Biostatistics, University of Washington, Seattle, Washington, United States of America, 3 Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, 4 Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada, 5 Departments of Medicine and Pathology, University of Washington, Seattle, Washington, United States of America Funding: This work was supported A B S T R A C T by grants HL53750, DK56465, HL54881, and DK47754 (to HPK) and Background HL065430–06 (to RKH) from the National Institutes of Health, Bethesda, Maryland, United States, Hematopoietic stem cells (HSCs) or repopulating cells are able to self-renew and differentiate and by a grant from the National into cells of all hematopoietic lineages, and they can be enriched using the CD34 cell surface Cancer Institute of Canada, Toronto, marker. Because of this unique property, HSCs have been used for HSC transplantation and Ontario, Canada (to RKH). HPK is a Markey Molecular Medicine gene therapy applications. However, the inability to expand HSCs has been a significant investigator.