原创力文档detection of mycolactone ab in mycobacterium ulcerans–infected human tissue在分枝杆菌细菌内酯的检测ab ulcerans-infected人体组织.pdfVIP
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detection of mycolactone ab in mycobacterium ulcerans–infected human tissue在分枝杆菌细菌内酯的检测ab ulcerans-infected人体组织
Detection of Mycolactone A/B in Mycobacterium
ulcerans–Infected Human Tissue
1 1,2 3 3 3
Fred Stephen Sarfo , Richard O. Phillips , Brian Rangers , Engy A. Mahrous , Richard E. Lee , Edward
4 5 3 4
Tarelli , Kingsley B. Asiedu , Pamela L. Small , Mark H. Wansbrough-Jones *
1 Komfo Anokye Teaching Hospital, Kumasi, Ghana, 2 School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, 3 University of
Tennessee Health Science Center, Memphis, Tennessee, United States of America, 4 St. George’s, University of London, London, United Kingdom, 5 World Health
Organization, Geneva, Switzerland
Abstract
Background: Mycobacterium ulcerans disease (Buruli ulcer) is a neglected tropical disease common amongst children in
rural West Africa. Animal experiments have shown that tissue destruction is caused by a toxin called mycolactone.
Methodology/Principal Findings: A molecule was identified among acetone-soluble lipid extracts from M. ulcerans (Mu)-
infected human lesions with chemical and biological properties of mycolactone A/B. On thin layer chromatography this
molecule had a retention factor value of 0.23, MS analyses showed it had an m/z of 765.6 [M+Na+] and on MS:MS
fragmented to produce the core lactone ring with m/z of 429.4 and the polyketide side chain of mycolactone A/B with m/z
of 359.2. Acetone-soluble lipids from lesions demonstrated significant cytotoxic, pro-apoptotic and anti-inflammatory
activities on cultured fibroblast and macrophage cell lines. Mycolactone A/B was detected in all of 10 tissue
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