donepezil impairs memory in healthy older subjects behavioural, eeg and simultaneous eegfmri biomarkers多奈哌齐会损害记忆老年受试者中健康行为,脑电图和同时eegfmri生物标志物.pdfVIP

Donepezil Impairs Memory in Healthy Older Subjects: Behavioural, EEG and Simultaneous EEG/fMRI Biomarkers 1 1 3 1 1 Joshua H. Balsters *, Redmond G. O’Connell , Mary P. Martin , Alessandra Galli , Sarah M. Cassidy , 1 1 1 4 4 Sophia M. Kilcullen , Sonja Delmonte , Sabina Brennan , Jim F. Meaney , Andrew J. Fagan , Arun L. W. 2 5 5,6 5 3 1 Bokde , Neil Upton , Robert Lai , Marc Laruelle , Brian Lawlor , Ian H. Robertson 1Trinity College Institute of Neuroscience and School of Psychology, Trinity College Dublin, Dublin, Ireland, 2 Trinity College Institute of Neuroscience and School of Medicine, Trinity College Dublin, Dublin, Ireland, 3 Mercer’s Institute for Research on Ageing, St. James’s Hospital, Dublin, Ireland, 4 Centre for Advanced Medical Imaging (CAMI), St. James’s Hospital, Trinity College Dublin, Dublin, Ireland, 5 Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, United Kingdom, 6 Neurosciences Discovery Medicine, GlaxoSmithKline, Harlow, United Kingdom Abstract Rising life expectancies coupled with an increasing awareness of age-related cognitive decline have led to the unwarranted use of psychopharmaceuticals, including acetylcholinesterase inhibitors (AChEIs), by significant numbers of healthy older individuals. This trend has developed despite very limited data regarding the effectiveness of such drugs on non-clinical groups and recent work indicates that AChEIs can have negative cognitive effects in healthy populations. For the firs