economic impact of dengue illness and the cost-effectiveness of future vaccination programs in singapore登革热疾病对经济的影响,并在新加坡未来的疫苗接种计划的成本效益.pdfVIP

Economic Impact of Dengue Illness and the Cost-Effectiveness of Future Vaccination Programs in Singapore 1 2 3,4,5 6 7 2 Luis R. Carrasco , Linda K. Lee , Vernon J. Lee , Eng Eong Ooi , Donald S. Shepard , Tun L. Thein , Victor Gan2, Alex R. Cook1,3,8*, David Lye2,9, Lee Ching Ng10, Yee Sin Leo2,9 1 Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore, 2 Communicable Disease Centre, Tan Tock Seng Hospital, Singapore, Singapore, 3 Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, 4 Biodefence Centre, Ministry of Defence, Singapore, Singapore, 5 Centre for Health Services Research, National University of Singapore, Singapore, Singapore, 6 Program in Emerging Infectious Diseases, Duke- NUS Graduate Medical School, Singapore, Singapore, 7 Brandeis University, Waltham, Massachusetts, United States of America, 8 Program in Health Services and Systems Research, Duke-NUS Graduate Medical School, Singapore, Singapore, 9 Department of Medicine, School of Medicine, National University of Singapore, Singapore, Singapore, 10 Environmental Health Institute, National Environment Agency, Singapore, Singapore Abstract Background: Dengue illness causes 50–100 million infections worldwide and threatens 2.5 billion people in the tropical and subtropical regions. Little is known about the disease burden and economic impact of dengue in higher resourced countries or the cost-effectiveness of potential dengue vaccines in such settings. Methods and Findings: We estimate the direct and indirect costs of dengue from hospitalized and ambulatory cases in Singapore. We consider inter alia the impacts of dengue on the economy using th