effect of ccr5-δ32 heterozygosity on hiv-1 susceptibility a meta-analysisccr5-δ32杂合度对hiv - 1的影响敏感性分析.pdfVIP

Effect of CCR5-D32 Heterozygosity on HIV-1 Susceptibility: A Meta-Analysis SiJie Liu, ChuiJin Kong, Jie Wu, Hao Ying, HuanZhang Zhu* The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China Abstract Background: So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-D32) can affect HIV-1 susceptibility. Methods: We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-D32 polymorphism was genotyped. Odds ratio (OR) with 95% confidence interval (CI) were employed to assess the association of CCR5-D32 polymorphism with HIV-1 susceptibility. Results: Compared with the wild-type CCR5 homozygotes, the pooled OR for CCR5-D32 heterozygotes was 1.02 (95%CI, 0.88–1.19) for healthy controls (HC) and 0.95 (95%CI, 0.71–1.26) for exposed uninfected (EU) controls. Similar results were found in stratified analysis by ethnicity, sample size and method of CCR5-D32 genotyping. Conclusions: The meta-analysis indicated that HIV-1 susceptibility is not significantly affected by heterozygosity for CCR5- D32. Citation: Liu S, Kong C, Wu J, Ying H, Zhu H (2012) Effect of CCR5-D32 Heterozygosity on HIV-1 Susceptibility: A Meta-Analysis. PLoS ONE 7(4): e35020. doi:10.1371/journal.pone.0035020 Editor: K.T. Jeang, National Institute of Health, United States of America Received October 29, 2011; Accepted March 8, 2012; Published April 4, 2012 Copyright: 2012 Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any med