effective elicitation of human effector cd8+ t cells in hla-b5101 transgenic humanized mice after infection with hiv-1有效启发人类的效应cd8 + t细胞在hla-b5101转基因人源化小鼠感染hiv - 1.pdfVIP

Effective Elicitation of Human Effector CD8+ T Cells in HLA-B*51:01 Transgenic Humanized Mice after Infection with HIV-1 Yoshinori Sato, Sayaka Nagata, Masafumi Takiguchi* Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto, Japan Abstract Humanized mice are expected to be useful as small animal models for in vivo studies on the pathogenesis of infectious diseases. However, it is well known that human CD8+ T cells cannot differentiate into effector cells in immunodeficient mice transplanted with only human CD34+ hematopoietic stem cells (HSCs), b