egr-2 is not required for in vivo cd4 t cell mediated immune responses不需要egr-2体内cd4 t细胞介导的免疫反应.pdfVIP

EGR-2 Is Not Required for In Vivo CD4 T Cell Mediated Immune Responses ´ 1 2 1 1 3 1 Hilda E. Ramon , Pedro J. Cejas , David LaRosa , Adeeb Rahman , John E. Harris , Jidong Zhang , 4 2 1 ¤ Christopher Hunter , Yongwon Choi , Laurence A. Turka * 1 Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 2 Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 3 Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, 4 Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America Abstract Background: The zinc finger transcription factor EGR-2 has been shown to play an important role in the induction of T cell anergy and the regulation of peripheral T cell tolerance. In vitro, a prior study has show that T cells deficient in EGR-2 are hyperproliferative to IL-2 and produce elevated levels of the effector cytokine IFN-c. EGR-2 deficient mice have increased levels of CD44high T cells in peripheral lymphoid organs, and with age, develop autoimmune-like features. Principal Findings: Here we show that despite increased numbers of cells bearing an activated CD44highCD62Llow phenotype, T cells from young healthy EGR-2 deficient mice have normal proliferative and cytokine responses, and the mice themselves mount normal immune responses against minor histocompatibility antigens, and the pathogens Toxoplasma gondii