evolution of thermal response properties in a cold-activated trp channel进化的热响应特性cold-activated trp通道.pdfVIP

Evolution of Thermal Response Properties in a Cold- Activated TRP Channel Benjamin R. Myers, Yaron M. Sigal, David Julius* Department of Physiology; University of California San Francisco, San Francisco, California, United States of America Abstract Animals sense changes in ambient temperature irrespective of whether core body temperature is internally maintained (homeotherms) or subject to environmental variation (poikilotherms). Here we show that a cold-sensitive ion channel, TRPM8, displays dramatically different thermal activation ran