fish-specific duplicated dmrt2b contributes to a divergent function through hedgehog pathway and maintains left-right asymmetry establishment functionfish-specific复制dmrt2b有助于发散函数通过hedgehog途径和保持左右不对称建立函数.pdfVIP

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fish-specific duplicated dmrt2b contributes to a divergent function through hedgehog pathway and maintains left-right asymmetry establishment functionfish-specific复制dmrt2b有助于发散函数通过hedgehog途径和保持左右不对称建立函数.pdf

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fish-specific duplicated dmrt2b contributes to a divergent function through hedgehog pathway and maintains left-right asymmetry establishment functionfish-specific复制dmrt2b有助于发散函数通过hedgehog途径和保持左右不对称建立函数

Fish-Specific Duplicated dmrt2b Contributes to a Divergent Function through Hedgehog Pathway and Maintains Left-Right Asymmetry Establishment Function Sha Liu, Zhi Li, Jian-Fang Gui* State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Wuhan, China Abstract Gene duplication is thought to provide raw material for functional divergence and innovation. Fish-specific dmrt2b has been identified as a duplicated gene of the dmrt2a/terra in fish genomes, but its function has remained unclear. Here we reveal that Dmrt2b knockdown zebrafish embryos display a downward tail curvature and have U-shaped somites. Then, we demonstrate that Dmrt2b contributes to a divergent function in somitogenesis through Hedgehog pathway, because Dmrt2b knockdown reduces target gene expression of Hedgehog signaling, and also impairs slow muscle development and neural tube patterning through Hedgehog signaling. Moreover, the Dmrt2b morphants display defects in heart and visceral organ asymmetry, and, some lateral-plate mesoderm (LPM) markers expressed in left side are randomized. Together, these data indicate that fish-specific duplicated dmrt2b contributes to a divergent function in somitogenesis through Hedgehog pathway and maintains the common function for left-right asymmetry establishment. Citation: Liu S, Li Z, Gui J-F (2009) Fish-Specific Duplicated dmrt2b Contributes to a Divergent Function through Hedgehog Pathway and Maintains Left-Right Asymmetry Establishment Function. PLoS ONE 4(9): e7261. doi:10.1371/journal.pone.0007261 Editor: Michael Hendricks, Harvard University, United States of America Received May 20, 2009; Accepted September 9, 2009; Published September 30, 2009 Copyright: 2009 Liu et al. This is an open-access article distributed u