fish and mammalian phagocytes differentially regulate pro-inflammatory and homeostatic responses in vivo鱼类和哺乳动物吞噬细胞不同调节体内促炎和稳态响应.pdfVIP
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fish and mammalian phagocytes differentially regulate pro-inflammatory and homeostatic responses in vivo鱼类和哺乳动物吞噬细胞不同调节体内促炎和稳态响应
Fish and Mammalian Phagocytes Differentially Regulate
Pro-Inflammatory and Homeostatic Responses In Vivo
1 1 1 1 1
Aja M. Rieger , Jeffrey D. Konowalchuk , Leon Grayfer , Barbara A. Katzenback , Jeffrey J. Havixbeck ,
Moira D. Kiemele1, Miodrag Belosevic1,2, Daniel R. Barreda1,3*
1 Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada, 2 School of Public Health, University of Alberta, Edmonton, Alberta, Canada,
3 Department of Agriculture, Forestry and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada
Abstract
Phagocytosis is a cellular mechanism that is important to the early induction of antimicrobial responses and the regulation
of adaptive immunity. At an inflammatory site, phagocytes serve as central regulators for both pro-inflammatory and
homeostatic anti-inflammatory processes. However, it remains unclear if this is a recent evolutionary development or
whether the capacity to balance between these two seemingly contradictory processes is a feature already displayed in
lower vertebrates. In this study, we used murine (C57BL/6) and teleost fish (C. auratus) in vitro and in vivo models to assess
the evolutionary conservation of this dichotomy at a site of inflammation. At the level of the macrophage, we found that
teleost fish already displayed divergent pro-inflammatory and homeostatic responses following internalization of zymosan
or apoptotic bodies, respectively, and that these were consistent with those of mice. However, fish and mice displayed
significant differences in vivo with regards to the level of responsiveness to zymosan and apoptotic bodies, the identity of
infiltrating leukocytes, their rate of infiltrat
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