five quantitative trait loci control radiation-induced adenoma multiplicity in mom1r apcmin+ mice五个控制辐射诱导腺瘤数量性状多样性mom1r apcmin +老鼠.pdfVIP

Five Quantitative Trait Loci Control Radiation-Induced Adenoma Multiplicity in Mom1R ApcMin/+ Mice 1. 1. 1 2 2 Eiram Elahi , Nirosha Suraweera , Emmanouil Volikos , Jackie Haines , Natalie Brown , Gerovie 3 3 4 5 1 Davidson , Mike Churchman , Mohammed Ilyas , Ian Tomlinson , Andrew Silver * 1 Colorectal Cancer Genetics, Institute for Cell and Molecular Sciences, Barts and The London, Queen Mary’s School of Medicine and Dentistry, London, United Kingdom, 2 HPA Radiation Protection Division, Chilton, Didcot, Oxon, United Kingdom, 3 Cancer Research UK Genotyping Facility, Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, Oxford, United Kingdom, 4 School of Molecular Medical Sciences, Division of Pathology, Queen’s Medical Centre, Nottingham, United Kingdom, 5 Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, United Kingdom Abstract Ionising radiation is a carcinogen capable of inducing tumours, including colorectal cancer, in both humans and animals. By backcrossing a recombinant line of ApcMin/+ mice to the inbred BALB/c mouse strain, which is unusually sensitive to radiation–induced tumour development, we obtained panels of 2Gy-irradiated and sham-irradiated N2 ApcMin/+ mice for genotyping with a genome-wide panel of microsatellites at ,15 cM density and phenotyping by counting adenomas in the small intestine. Interval and composite interval mapping along with permutation testi