genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity脂肪性状的遗传和基因组分析复杂的继承显示显著性特征.pdfVIP

Genetic and Genomic Analysis of a Fat Mass Trait with Complex Inheritance Reveals Marked Sex Specificity 1[ 1[ 2[ 3 4 1,5,6,7* Susanna Wang , Nadir Yehya , Eric E. Schadt , Hui Wang , Thomas A. Drake , Aldons J. Lusis 1 Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, 2 Rosetta Inpharmatics, Seattle, Washington, United States of America, 3 Department of Statistics, College of Letters and Science, University of California Los Angeles, Los Angeles, California, United States of America, 4 Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, 5 Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, 6 Department of Microbiology, Immunology, and Molecular Genetics, College of Letters and Science, University of California Los Angeles, Los Angeles, California, United States of America, 7 Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes. The effects of gender on the regulation of many physiological traits are well documented; however, ‘‘genetical genomic’’ analyses have not yet addressed the degree to which their conclusions are affected by sex. We constructed and densely genotyped a large F2 intercross derived from the inbred mouse strains C57BL/6J and C3H/HeJ on an apolipoprotein E null (ApoE/) background