genetic epidemiology of glioblastoma multiforme confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs遗传流行病学的多形性成胶质细胞瘤确认和新发现的分析人类白细胞抗原等位基因和主题.pdfVIP

Genetic Epidemiology of Glioblastoma Multiforme: Confirmatory and New Findings from Analyses of Human Leukocyte Antigen Alleles and Motifs 1 2 1 3 3 1 Wei Song , Avima M. Ruder , Liangyuan Hu , Yufeng Li , Rong Ni , Wenshuo Shao , Richard A. 1,3 2 3 Kaslow , MaryAnn Butler , Jianming Tang * 1 Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 2 National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, United States of America, 3 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America Abstract Background: Human leukocyte antigen (HLA) class I genes mediate cytotoxic T-lymphocyte responses and natural killer cell function. In a previous study, several HLA-B and HLA-C alleles and haplotypes were positively or negatively associated with the occurrence and prognosis of glioblastoma multiforme (GBM). Methodology/Principal Findings: As an extension of the Upper Midwest Health Study, we have performed HLA genotyping for 149 GBM patients and 149 healthy control subjects from a non-metropolitan population consisting almost exclusively of European Americans. Conditional logistic regression models did not reproduce the association of HLA-B*07 or the B*07-Cw*07 haplotype with GBM. Nonetheless, HLA-A*32, which has previously been shown to predispose GBM patients to a favorable prognosis, was negatively associated with occurrence of GBM (odds ratio = 0.41, p = 0.04 by univariate analysis). Other alleles (A*29, A*30, A*31 and A*33) within the A19 serology group to which A*32 belongs showed inconsistent trends. Sequencing- based H