histone h4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in saccharomyces cerevisiae12组蛋白h4赖氨酸乙酰化调节端粒的异染色质在酿酒酵母可塑性.pdfVIP
- 1、本文档共11页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
histone h4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in saccharomyces cerevisiae12组蛋白h4赖氨酸乙酰化调节端粒的异染色质在酿酒酵母可塑性
Histone H4 Lysine 12 Acetylation Regulates Telomeric
Heterochromatin Plasticity in Saccharomyces cerevisiae
1 1 1 1 1 2
Bo O. Zhou , Shan-Shan Wang , Yang Zhang , Xiao-Hong Fu , Wei Dang , Brian A. Lenzmeier , Jin-Qiu
Zhou1*
1 State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,
Shanghai, China, 2 School of Science, Buena Vista University, Storm Lake, Iowa, United States of America
Abstract
Recent studies have established that the highly condensed and transcriptionally silent heterochromatic domains in budding
yeast are virtually dynamic structures. The underlying mechanisms for heterochromatin dynamics, however, remain obscure.
In this study, we show that histones are dynamically acetylated on H4K12 at telomeric heterochromatin, and this acetylation
regulates several of the dynamic telomere properties. Using a de novo heterochromatin formation assay, we surprisingly
found that acetylated H4K12 survived the formation of telomeric heterochromatin. Consistently, the histone
acetyltransferase complex NuA4 bound to silenced telomeric regions and acetylated H4K12. H4K12 acetylation prevented
the over-accumulation of Sir proteins at telomeric heterochromatin and elimination of this acetylation caused defects in
multiple telomere-related processes, including transcription, telomere replication, and recombination. Together, these data
shed light on a potential histone acetylation mark within telomeric heterochromatin that contributes to telomere plasticity.
Citation: Zhou BO, Wang S-S, Zhang Y, Fu X-H, Dang W, et al. (2011) Histone H4 Lysine 12 Acetylation Regulates Telomeri
您可能关注的文档
- health risk or resource gradual and independent association between self-rated health and mortality persists over 30 years健康风险或资源逐渐和独立的自我评估健康和死亡率之间的联系持续超过30年.pdf
- health seeking behaviour and utilization of health facilities for schistosomiasis-related symptoms in ghana求医行为和卫生设施的利用率schistosomiasis-related症状在加纳.pdf
- hcv causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response丙肝病毒引起慢性内质网应激导致适应和干扰展开的蛋白质反应.pdf
- health services for buruli ulcer control lessons from a field study in ghana卫生服务布鲁里溃疡控制领域研究的教训在加纳.pdf
- healthier fundraising in u. s. elementary schools associations between policies at the state, district, and school levels健康筹款在美国小学政策之间的关联状态,区,和学校的水平.pdf
- health system resource gaps and associated mortality from pandemic influenza across six asian territories卫生系统资源缺口和相关死亡率大流行性流感在6个亚洲地区.pdf
- health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia健康相关的生活质量长期复发儿童急性淋巴细胞白血病的幸存者.pdf
- healthy growth in children with down syndrome唐氏综合症儿童的健康成长.pdf
- healthy lifestyle and leukocyte telomere length in u.s. women美国女性健康的生活方式和白细胞端粒长度.pdf
- hearing travelling wave or resonance听到行波共振.pdf
- 5.5.1两角差的余弦公式课件(4)高一上学期数学人教A版.pptx
- 猜猜我是谁(课件)三年级下册综合实践活动沪科黔科版.pptx
- 4.2元素周期律课件高一化学上学期人教版6.pptx
- 人类与地理环境的互动.pptx
- 暑假作业02现在完成时.docx
- ChinaDaily改编语法填空专项练习高三英语二轮复习2.docx
- 八年级英语下册《Unit8HaveyoureadTreasureIslandyetSectionA2》课件(完整版)2.pptx
- 二年级上册专项训练之句子.pptx
- 2024年中考英语复习被动语态课件.pptx
- Unit4Ihaveaball.Lesson23(课件)人教精通版英语三年级上册(1).pptx
最近下载
- 部编版八年级上册历史基础知识填空.docx
- 小学五年级上全册人自然社会教案可打印.doc
- DB11∕T 1598.3-2019 居家养老服务规范 第3部分:助医服务.docx VIP
- 人教版高中物理电学实验要点总结.pdf VIP
- 普通高中课程标准2023.pdf
- 幼儿园幼儿出游安全应急预案.docx VIP
- 2024浙江省执业药师继续教育答案-中医虚症辨证用药.docx VIP
- DB11_T 1598.2-2019 居家养老服务规范 第2部分:助餐服务.PDF VIP
- 简谱 爱永在 沂蒙山 王传亮.pdf
- 小学一年级音乐下(第三单元 音乐中的动物: 唱歌 咏鹅):C1跨学科学习活动设计-教学方案设计+学生学习成果+学习成果点评[2.0微能力获奖优秀作品].docx
文档评论(0)