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human t cell leukemia virus reactivation with progression of adult t-cell leukemia-lymphoma人类t细胞白血病病毒再活化与成人t细胞leukemia-lymphoma进展.pdf

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human t cell leukemia virus reactivation with progression of adult t-cell leukemia-lymphoma人类t细胞白血病病毒再活化与成人t细胞leukemia-lymphoma进展

Human T Cell Leukemia Virus Reactivation with Progression of Adult T-Cell Leukemia-Lymphoma 1 2 1 3 3 4 Lee Ratner *, William Harrington , Xuan Feng , Christian Grant , Steve Jacobson , Ariela Noy , Joseph 5 6¤ 7 1 8 Sparano , Jeannette Lee , Richard Ambinder , Nancy Campbell , Michael Lairmore for the AIDS Malignancy Consortium 1 Division of Oncology, Washington University School of Medicine, St Louis, Missouri, United States of America, 2 University of Miami School of Medicine, Miami, Florida, United States of America, 3 Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America, 4 Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, 5 Department of Oncology, Albert Einstein College of Medicine, Bronx, New York, United States of America, 6 Division of Hematology/Oncology, University of Alabama School of Medicine, Birmingham, Alabama, United States of America, 7 Department of Oncology, Johns Hopkins University Medical Institutions, Baltimore, Maryland, United States of America, 8 Center for Retrovirus Research, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, United States of America Abstract Background: Human T-cell leukemia virus-associated adult T-cell leukemia-lymphoma (ATLL) has a very poor prognosis, despite trials of a variety of different treatment regimens. Virus expression has been reported to be limited or absent when ATLL is diagnosed, and this has suggested that secondary genetic or epigenetic chan