原创力文档histological criteria for encapsulating peritoneal sclerosis – a standardized approach组织学标准封装腹膜硬化u2014u2014一个标准化的方法.pdfVIP
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histological criteria for encapsulating peritoneal sclerosis – a standardized approach组织学标准封装腹膜硬化u2014u2014一个标准化的方法
Histological Criteria for Encapsulating Peritoneal
Sclerosis – A Standardized Approach
1 2 3 1 1 2
Niko Braun , Peter Fritz , Christoph Ulmer , Joerg Latus *, Martin Kimmel , Dagmar Biegger ,
4 1,5 3 6 7
German Ott , Fabian Reimold , Klaus-Peter Thon , Juergen Dippon , Stephan Segerer , M.
Dominik Alscher1
1 Department of Internal Medicine, Division of Nephrology, Robert Bosch Hospital, Stuttgart, Germany, 2 Margarete Fischer–Bosch Institute of Clinical Pharmacology,
University of Tuebingen, Tuebingen, Germany, 3 Department of Surgery, Robert Bosch Hospital, Stuttgart, Germany, 4 Department of Diagnostic Medicine, Division of
Pathology, Robert Bosch Hospital, Stuttgart, Germany, 5 Department of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of
America, 6 Department of Mathematics, University of Stuttgart, Stuttgart, Germany, 7 Division of Nephrology, University Hospital, Zurich, Switzerland
Abstract
Background: The two most relevant pathologies of long-term peritoneal dialysis (PD) are simple sclerosis and encapsulating
peritoneal sclerosis (EPS). The histological differentiation of those two entities is difficult. The Aim of the study was to
establish a method to standardize and facilitate the differentiation between simple sclerosis and EPS
Methods: We investigated 58 peritoneal biopsies - 31 EPS patients and 27 PD patients. Two blinded investigators analyzed
20 histological characteristics in EPS and PD patients.
Results: The following findings were significantly more common in EPS than in patients on PD without EPS: fibroblast lik
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