hcv tumor promoting effect is dependent on host genetic background丙肝病毒肿瘤促进作用依赖于宿主遗传背景.pdfVIP
- 1、本文档共11页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
hcv tumor promoting effect is dependent on host genetic background丙肝病毒肿瘤促进作用依赖于宿主遗传背景
HCV Tumor Promoting Effect Is Dependent on Host
Genetic Background
1 2 3 4 1
Naama Klopstock , Mark Katzenellenbogen , Orit Pappo , Miriam Sklair-Levy , Devorah Olam , Lina
1 1 1 1
Mizrahi , Tamara Potikha , Eithan Galun , Daniel Goldenberg *
1 Goldyne Savad Institute of Gene Therapy, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, 2 Bioinformatics and Microarray Unit, The Mina and Everard
Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel, 3 Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel,
4 Breast Imaging Center, Sheba Medical Center, Tel Hashomer, Israel
Abstract
Background: The hepatitis C virus (HCV) is one of the major risk factors for the development of hepatocellular carcinoma
(HCC). Nevertheless, transgenic mice which express the whole HCV polyprotein (HCV-Tg) do not develop HCC. Whereas
chronic HCV infection causes inflammation in patients, in HCV-Tg mice, the host immune reaction against viral proteins is
lacking. We aimed to test the role of HCV proteins in HCC development on the background of chronic inflammation in vivo.
Methodology/Principal Findings: We crossed HCV-Tg mice that do not develop HCC with the Mdr2-knockout (Mdr2-KO)
mice which develop inflammation-associated HCC, to generate Mdr2-KO/HCV-Tg mice. We studied the effect of the HCV
transgene on tumor incidence, hepatocyte mitosis and apoptosis, and investigated the potential contributing factors for the
generated phenotype by gene expression and protein analyses. The Mdr2-KO/HCV-Tg females from the N2 generation of
this breeding (having 75% of the FVB/N genome and 25% of the C57BL/6 gen
您可能关注的文档
- genotype and ancestry modulate brain's dat availability in healthy humans基因型和祖先在健康人体内调节大脑的dat的可用性.pdf
- genotoxic exposure during juvenile growth of mammary gland depletes stem cell activity and inhibits wnt signaling不会暴露在少年乳腺干细胞活动消耗的增长和抑制wnt信号.pdf
- genotype at the p554l variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness基因型在p554l hexose-6磷酸脱氢酶基因的变异与颈动脉intima-medial厚度有关.pdf
- genotype v japanese encephalitis virus is emerging基因型v日本脑炎病毒出现.pdf
- genotype-temperature interaction in the regulation of development, growth, and morphometrics in wild-type, and growth-hormone transgenic coho salmongenotype-temperature互动发展的规定,增长,在野生型的形态学、生长激素转基因银鲑鱼.pdf
- genotypic and pfgemlva analyses of vibrio cholerae o1 geographical spread and temporal changes during the 2007–2010 cholera outbreaks in thailand基因型和pfgemlva分析霍乱弧菌o1群的地理分布和时间变化在2007 - 2010年在泰国霍乱暴发.pdf
- genotypic and phenotypic characterization of chikungunya virus of different genotypes from malaysia齐昆古尼亚病毒基因型和表型鉴定从马来西亚不同的基因型.pdf
- genotypic and phenotypic properties of cattle-associated campylobacter and their implications to public health in the usacattle-associated弯曲杆菌的基因型和表型特性及其对公众健康的影响在美国.pdf
- genotypic diversity and drug susceptibility patterns among m. tuberculosis complex isolates from south-western ghana结核分枝杆菌基因型多样性和药敏模式之间复杂的隔离从西南加纳.pdf
- genotypic homogeneity of multidrug resistant s. typhimurium infecting distinct adult and childhood susceptibility groups in blantyre, malawi基因型耐药金黄色的同质性沙门氏菌感染感染不同的成人和儿童在布兰太尔敏组,马拉维.pdf
文档评论(0)