hdac6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neuronshdac6抑制剂阻断淀粉样beta-induced损伤海马神经元线粒体运输.pdfVIP
- 1、本文档共7页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
hdac6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neuronshdac6抑制剂阻断淀粉样beta-induced损伤海马神经元线粒体运输
HDAC6 Inhibitor Blocks Amyloid Beta-Induced
Impairment of Mitochondrial Transport in Hippocampal
Neurons
1. 1. 1 1 2,3 2,3
Chaeyoung Kim , Heesun Choi , Eun Sun Jung , Wonik Lee , Soojung Oh , Noo Li Jeon ,
Inhee Mook-Jung1*
1 Department of Biochemistry and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, 2 School of Mechanical and Aerospace Engineering,
Seoul National University, Seoul, Korea, 3 World Class University (WCU) Program of Multiscale Design, School of Mechanical and Aerospace Engineering, Seoul National
University, Seoul, Korea
Abstract
Even though the disruption of axonal transport is an important pathophysiological factor in neurodegenerative diseases
including Alzheimer’s disease (AD), the relationship between disruption of axonal transport and pathogenesis of AD is
poorly understood. Considering that a-tubulin acetylation is an important factor in axonal transport and that Ab impairs
mitochondrial axonal transport, we manipulated the level of a-tubulin acetylation in hippocampal neurons with Ab cultured
in a microfluidic system and examined its effect on mitochondrial axonal transport. We found that inhibiting histone
deacetylase 6 (HDAC6), which deacetylates a-tubulin, significantly restored the velocity and motility of the mitochondria in
both anterograde and retrograde axonal transports, which would be otherwise compromised by Ab. The inhibition of
HDAC6 also recovered the length of the mitochondria that had been shortened by Ab to a normal level. These results
suggest that the inhibition of HDAC6 significantly rescues hippocampal neurons from Ab-induced
您可能关注的文档
- genomics of adaptation during experimental evolution of the opportunistic pathogen pseudomonas aeruginosa实验期间适应进化的基因组学的机会病原体铜绿假单胞菌.pdf
- genomics of emerging infectious disease a plos collection基因组学的新兴传染病公共科学图书馆收藏.pdf
- genomics research and malaria control great expectations基因组学研究和疟疾控制远大前程.pdf
- genomos study finds weak links between col1a1 polymorphism, bmd, and fracture riskgenomos col1a1多态性之间的研究发现薄弱环节,骨密度和骨折风险.pdf
- genomotyping of coxiella burnetii using microarrays reveals a conserved genomotype for hard tick isolatesgenomotyping伯纳特氏立克次氏体使用微阵列显示一个守恒genomotype硬蜱虫隔离.pdf
- genotype and ancestry modulate brain's dat availability in healthy humans基因型和祖先在健康人体内调节大脑的dat的可用性.pdf
- genotoxic exposure during juvenile growth of mammary gland depletes stem cell activity and inhibits wnt signaling不会暴露在少年乳腺干细胞活动消耗的增长和抑制wnt信号.pdf
- genotype at the p554l variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness基因型在p554l hexose-6磷酸脱氢酶基因的变异与颈动脉intima-medial厚度有关.pdf
- genotype v japanese encephalitis virus is emerging基因型v日本脑炎病毒出现.pdf
- genotype-temperature interaction in the regulation of development, growth, and morphometrics in wild-type, and growth-hormone transgenic coho salmongenotype-temperature互动发展的规定,增长,在野生型的形态学、生长激素转基因银鲑鱼.pdf
文档评论(0)