mortality among patients with cleared hepatitis c virus infection compared to the general population a danish nationwide cohort study清除丙型肝炎病毒感染患者的死亡率与一般人群相比,丹麦全国队列研究.pdfVIP

Mortality among Patients with Cleared Hepatitis C Virus Infection Compared to the General Population: A Danish Nationwide Cohort Study 1 2 3 4,5 6 Lars Haukali Omland *, Peer Brehm Christensen , Henrik Krarup , Peter Jepsen , Nina Weis , Henrik 4,7 1 Toft Sørensen , Niels Obel , on behalf of the DANVIR Cohort Study 1 Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, 2 Department of Infectious Diseases, Odense University Hospital, Odense, Denmark, 3 Department of Clinical Biochemistry, Aarhus University Hospital, Aalborg Hospital, Aalborg, Denmark, 4 Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark, 5 Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Aarhus, Denmark, 6 Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre Hospital, Copenhagen, Denmark, 7 Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America Abstract Background: The increased mortality in HCV-infected individuals partly stems from viral damage to the liver and partly from risk-taking behaviours. We examined mortality in patients who cleared their HCV-infection, comparing it to that of the general population. We also addressed the question whether prognosis differed according to age, substance abuse (alcohol abuse and injection drug use) and comorbidity. Methodology/Principal Findings: Patients with cleared HCV-infection were categorized into one of 8 groups according to