no evidence for infection of uk prostate cancer patients with xmrv, bk virus, trichomonas vaginalis or human papilloma viruses没有证据表明英国感染的前列腺癌患者xmrv,bk病毒、阴道毛滴虫或人类乳头状瘤病毒.pdfVIP

No Evidence for Infection of UK Prostate Cancer Patients with XMRV, BK Virus, Trichomonas vaginalis or Human Papilloma Viruses 1 2 3 1 Harriet C. T. Groom , Anne Y. Warren , David E. Neal , Kate N. Bishop * 1 Division of Virology, MRC National Institute for Medical Research, London, United Kingdom, 2 Department of Pathology, University of Cambridge, Cambridge, United Kingdom, 3 Department of Oncology, University of Cambridge, Cambridge, United Kingdom Abstract The prevalence of specific infections in UK prostate cancer patients was investigated. Serum from 84 patients and 62 controls was tested for neutralisation of xenotropic murine leukaemia virus-related virus (XMRV) Envelope. No reactivity was found in the patient samples. In addition, a further 100 prostate DNA samples were tested for XMRV, BK virus, Trichomonas vaginalis and human papilloma viruses by nucleic acid detection techniques. Despite demonstrating DNA integrity and assay sensitivity, we failed to detect the presence of any of these agents in DNA samples, bar one sample that was weakly positive for HPV16. Therefore we conclude that these infections are absent in this typical cohort of men with prostate cancer. Citation: Groom HCT, Warren AY, Neal DE, Bishop KN (2012) No Evidence for Infection of UK Prostate Cancer Patients with XMRV, BK Virus, Trichomonas vaginalis or Human Papilloma Viruses. PLoS ONE 7(3): e34221. doi:10.1371/journal.pone.0034221 Editor: Mark Wainberg, McGill University AIDS Centre, Canada Received November 22, 2011; Accepted February 24, 2012; Published March 28, 2012 Copyright: 2012 Groom et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricte