non-invasive molecular imaging of fibrosis using a collagen-targeted peptidomimetic of the platelet collagen receptor glycoprotein vi非侵入性纤维化的分子成像使用collagen-targeted peptidomimetic血小板的胶原蛋白受体糖蛋白vi.pdfVIP

Non-Invasive Molecular Imaging of Fibrosis Using a Collagen-Targeted Peptidomimetic of the Platelet Collagen Receptor Glycoprotein VI 1,5. 2,5,6. ´ 1,5 2,5,6 Julien Muzard , Laure Sarda-Mantel , Stephane Loyau , Alain Meulemans , Liliane 1,5 4,5 5 ¨ 4,5 Louedec , Claudie Bantsimba-Malanda , Florence Hervatin , Joelle Marchal-Somme , Jean Baptiste 1,5,6 2,5,6 3 1,5,6 Michel , Dominique Le Guludec , Philippe Billiald , Martine Jandrot-Perrus * ˆ ´ 1 INSERM, U698, Hopital Bichat, Paris, France, 2 INSERM, U773, CRB3, Faculte Xavier Bichat, Paris, France, 3 Museum National d’Histoire Naturelle, CNRS-FRE 3206, Paris, ´ ´ ˆ France, 4 INSERM, U700, Faculte Xavier Bichat, Paris, France, 5 Universite Paris7, Paris, France, 6 AP-HP, Hopital Bichat, Paris, France Abstract Background: Fibrosis, which is characterized by the pathological accumulation of collagen, is recognized as an important feature of many chronic diseases, and as such, constitutes an enormous health burden. We need non-invasive specific methods for the early diagnosis and follow-up of fibrosis in various disorders. Collagen targeting molecules are therefore of interest for potential in vivo imaging of fibrosis. In this study, we developed a coll