not all missed doses are the same sustained nnrti treatment interruptions predict hiv rebound at low-to-moderate adherence levels并不是所有错过的剂量是相同的持续nnrti治疗中断预测艾滋病反弹中度依从性水平.pdfVIP

Not All Missed Doses Are the Same: Sustained NNRTI Treatment Interruptions Predict HIV Rebound at Low-to- Moderate Adherence Levels 1,2 3 ´ 2 5 Jean-Jacques Parienti *, Moupali Das-Douglas , Veronique Massari , David Guzman , Steven G. 3 1 4 Deeks , Renaud Verdon , David R. Bangsberg ˆ 1 Clinical Research and Biostatistics, and Infectious Diseases Departments, Cote de Nacre University Hospital, Caen, France, 2 Pierre et Marie Curie University Paris 6, UMR S707 and INSERM U707, Paris, France, 3 Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, and The Positive Health Program, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America, 4 Partners AIDS Research Center, Massachusetts General Hospital, Harvard University, Boston, Massachusetts, United States of America, 5 Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, University of California San Francisco, San Francisco, California, United States of America Abstract Background: While the relationship between average adherence to HIV potent antiretroviral therapy is well defined, the relationship between patterns of adherence within adherence strata has not been investigated. We examined medication event monitoring system (MEMS) defined adherence patterns and their relation to subsequent virologic rebound. Methods and Results: We selected subjects with at least 3-months of previous virologic suppression on a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen from two prospective cohorts in Fran